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Endocrinology 136:660667 Bellush LL, Doublier S, Holland AN, Striker LJ, Striker GE, Kopchick JJ (2000) Protection against diabetes-induced nephropathy in growth hormone receptor/binding protein gene-disrupted mice

Introducing AOD-9604 during this natural lipolytic window amplifies the effect

Guidelines NICE (UK), NHS MSK pathways, and British Society for Surgery of the Hand These typically recommend: Conservative management first, including: Activity modification NSAIDs Splinting (usually 26 weeks) RCT evidence: 2023 JAMA Network Open Systematic Review & Network Metaanalysis (30 RCTs, n=1,663) Findings: Corticosteroid injection + thumb spica splint = best outcomes for pain and function

Growth hormone secretagogues, for example, prompt the pituitary gland to release more of its own growth hormone

J Endocrinol 166 : 579590 Coschigano KT et al

Masebas, W., Chabik, G