Altered intestinal permeability (leaky gut) allows the passage of food antigens, toxins, bacteria, and microbial products, promoting inflammation and dysregulated immune responses, triggering autoimmunity through various mechanisms [188]
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For instance, through blockade of lipid peroxidation as well as by reinforcing intracellular antioxidant capacity, as demonstrated by reduced levels of peroxidation products like MDA/thiobarbituric acid reactive species (TBARS) and elevated antioxidant defences such as SOD, GSH, GST and CAT, Moringa oleifera extracts showed enhanced effects in protecting against the detrimental effects of oxidative stress in preclinical models of T1D (Jaiswal et al., 2013
Cancer Research Communications 5(9):1566-1573, 2025
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