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Slow dose increases and close medical follow-up help reduce discomfort

The drug creates a positive feedback loop where weight loss improves the metabolic environment, which makes further metabolic normalization easier

For context, side effects caused about 5% of people to stop semaglutide and about 7% to stop tirzepatide in similar weight-loss trials

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This is a standard and ethically required feature of Phase 3 studies

It preserves muscle mass, supports metabolic health, stabilizes glucose, and protects bone density