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Clinical data show that weight regain is common after GLP-1 medications are discontinued, including a STEP 1 trial extension where participants regained about two-thirds of prior weight loss one year after stopping semaglutide and lifestyle intervention

In practice, the best evidence for modest fat and weight loss in humans points to l-carnitine when it is combined with solid diet and regular exercise

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Later retracted due to data fabrication concerns involving Kawas and Harding [Benoist et al., 2014 RETRACTED]

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Compounded tirzepatide uses the same active drug and can cost less, but it does not get FDA review and has a much narrower legal path in 2026