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Support for the Nervous System: B12 is critical for the maintenance of myelin, the protective sheath around nerves

For the Schilling test flushing dose, 1000mcg should be administered IM

This supports reduced fatigue, improved stamina, and faster recovery in patients with vitamin deficiency or illness-related weakness

In contrast, there is some evidence of an enhancement of the maximum absorption via intrinsic factor, by up to a factor of 2, when the vitamin B12 is accompanied by food, but this is not consistently observed and probably only applies when the food quantity and vitamin B12 dose are sufficient to slow the passage of the vitamin B12 through the small intestine enough (about three hours or more) to allow each intrinsic factor receptor to absorb two molecules of vitamin B12 from the oral dose rather than one

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But it may cause more discomfort during insertion