Conditions for which this effect has been demonstrated are: glutaric aciduria II, methyl malonic aciduria, propionic acidemia, and medium chain fatty acylCoA dehydrogenase deficiency
This remains the most-cited clinical comparison for topical copper peptide efficacy
Although these tiny bubbles are impervious to digestive juices and protect their valuable contents from oxidative degradation, they can be damaged with heat or violent agitation
Dooley, C
In contrast, Coulter and Allen (1981) recommended reducing the dose of VPA when the ammonia concentration exceeds 100 g/dl (71 mol/L) [10]
Copper peptides should be avoided by anyone with a known copper allergy, those with active inflammatory skin conditions like a rosacea flare or severe eczema, anyone whose skin barrier is severely compromised, and (until more research is available) those who are pregnant or breastfeeding