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10.1038/cddis.2017.28 Summary Keywords GLP-1, oral delivery, vagal afferents, diabetes, obesity, peptide Citation New RRC, Bogus M, Travers GN, Hahn U, Vaiceliunaite A, Burnet M, Wang JH and Wen H (2024) Glucagon-like peptide-1 receptor agonists for treatment of diabetes and obesity: advantage of oral delivery

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According to the European Medicines Agency assessment report on HPL, lyophilized 65% ethanol extracts (5:1, 100 mg of extracts were equivalent to 500 mg of HPL) were standardized to 0.3% hypericin and contained 1.09% rutin, 0.65% hyperoside, 0.45% isoquercitin, 0.04% quercitrin, and 0.07% quercetin (the HPL flavonoid content determination is described in Supplementary method I, Supplementary Figure S1, and Supplementary Tables S1, S2)

Escitalopram (Cipralex or Lexapro) is the preferred prescribed antidepressant to breast cancer patients who are on tamoxifen, as it interacts less in the conversion of tamoxifen into endoxifen compared to other antidepressants such as fluoxetine 53