Various chemical modifications such as PEGylation, glycosylation, and lipidation have enhanced its stability and bioavailability to safeguard catalase from enzymatic degradation and immune recognition
The mechanisms are complementary on paper
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Beyond the obesity indication, they are studying retatrutide for type 2 diabetes (TRIUMPH-2), obstructive sleep apnea (TRIUMPH-3), and cardiovascular outcomes
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Future work should focus on understanding how the biomolecular composition of Pseudodesulfovibrio sp