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Dihexa binds to hepatocyte growth factor (HGF) with high affinity ( K d =65 pM) and potentiates its activity at its receptor, c-Met
Cells were fixed with 4% PFA for 30 minutes, permeabilized with 0.1% Triton X-100, and blocked with 5% normal goat or donkey serum
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The first part of the study began by randomly dividing the test subjects in four groups including: wild type, APP/PS1, APP/PS1 + Dihexa administered at a dose of 1.44 mg/kg, and APP/PS1 + Dihexa administered at a dose of 2.88 mg/kg [1]
Unfortunately the SFI could not be calculated by the research team as there was poor toe to toe print separation
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