glp-1 and prostate cancer Glucagon-like peptide-1 receptor agonists in neoplastic diseases GLP1 receptor agonism alters growth

Given the emerging role for ferroptosis in antitumor immunity, we tested lipophilic statins including simvastatin alone and in combination with -PD1 in vivo and found that simvastatin and -PD1 promoted tumor clearance and extended survival in 20% to 60% of mice alone but in nearly 100% of mice when administered together

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[DOI] [PubMed] [Google Scholar] 2.Marx RE

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EBioMedicine 76:103847

Apr 1990;70(4):1007-1013