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[DOI] [PMC free article] [PubMed] [Google Scholar] Supinski GS, Stofan D, Ciufo R, et al

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A sedentary lifestyle with lowered expression of PGC-1alpha is associated with weight gain, inflammation, and decreased insulin secretion, pathological changes that eventually culminate in T2DM and obesity (191) (Table 3)

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GHK-Cu the copper tripeptide glycyl-L-histidyl-L-lysine complexed with copper(II) has a long and specific research history as an injected, systemically distributed molecule, and that is the only route this article addresses