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Mechanisms of cardiovascular benefits of sodium glucose co-transporter 2 (SGLT2) inhibitors: a state-of-the-art review
Material is supplied in sealed laboratory vials to promote reproducibility, documentation, and traceability in analytical and investigational research environments
For GLP-1, the review confirmed insulinotropic effects on -cells during hyperglycaemia, glucagonostatic effects on -cells during hyperglycaemia (indirect, via somatostatin and insulin), gastric emptying delay, CNS appetite suppression, and indirect promotion of lipolysis via increased sympathetic activity
In vitro treatment of high glucose for 72 h resulted in higher ROS accumulation and potentiated TGF pathway activation in PSCs
In addition to antioxidant and anti-inflammatory properties, HTY has been reported to exhibit antimicrobial properties, potentially through inhibiting the pathogens access to ATP synthase through binding to the ATP synthase polyphenol binding pocket [11] as well as cardioprotective and neuroprotective effects linked to improved endothelial function, lipid oxidation control, and attenuation of oxidative stress [12,13,14,15,16]
