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However, studies in animals have shown that semaglutide interacts with the circumventricular regions and specifically accesses GLP-1Rpositive brain regions following peripheral administration, including the area postrema in the hindbrain, the arcuate nucleus of the hypothalamus, and the lateral septal nucleus [50]

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The reductions in mean FPG, mean sevenpoint SMPG and incremental SMPG were significantly greater with both doses of semaglutide than with sitagliptin (Table 2)

No, both medications should be avoided in pregnancy