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Both these receptors are activated by similar types of short chain fatty acids (292), and both these signal through an inhibitory G type protein, but FFAR2 is also capable to signal through Gq/11 proteins (293) by which it has shown to mediate GLP-1 and PYY secretion in vitro and in vivo (82, 295)

This explains why muscle fatigue on GLP-1s often worsens when people drink more water trying to combat tiredness

Of course, there is a theoretical performance advantage in sports that have weight classes or sports like cycling and long distance running where weight is a factor, but because the GLP-1s suppress appetite and cause muscle loss as well as fat loss, they arent necessarily going to improve performance. However, Eichner also points out that not much is known about potential performance-enhancing effects of GLP-1s, and more research needs to be done

doi: 10.1210/endo.133.1.8319572 [DOI] [PubMed] [Google Scholar] 47

We are also carefully examining whether Exendin-4 can have an effect in stimulating the bodys production of insulin, he said

In another study, an Y1R agonist and Y2R antagonist reduced alcohol drinking-in-the-dark in C57BL/6J mice (Sparrow et al., 2012)