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A 2019 open clinical trial published in Frontiers treated 51 ME/CFS patients with high-dose hydroxocobalamin nasal drops to bypass the gut

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The peptide appears to promote mucosal healing through enhancement of epithelial cell proliferation and migration, restoration of tight junction integrity, and modulation of inflammatory responses within the gastrointestinal tract

Supplementation has been shown to improve sperm motility, possibly by supporting mitochondrial function

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