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Indeed the activation of prodrugs in GST overexpressing cells may lead to high concentrations of an active drug, as compared to normal cells with moderate enzyme levels
310 In an in vivo diabetic cardiomyopathy model, pifithrin- impaired angiogenesis, restored cellular senescence, and decreased glycolysis by suppressing the transcription of p53-dependent target genes, including HIF-1, p16, p21, p16, glucose transporter 1 (GLUT-1), and glucose transporter 4 (GLUT-4)
Confirmed through bioinformatics analyses and clinical samples, these biomarkers are involved in critical pathways, including cytokine interaction and cellular responses to oxidative stress
doi: 10.1677/joe.0.1500077
It dissolves readily in water and requires no carrier for application