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This leads to uncertainty behind the actual mechanism of Akkermansia supplementation, as far as whether Akkermansia actually stays in the body when administered, whether supplementation has only temporary or long-lasting effects, and if supplementation can aid the natural composition of Akkermansia or not

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For example, oxidized cysteine (cystine) makes Salmonella enterica more sensitive to gentamicin by disrupting the intracellular redox balance, altered the GSH/GSSG ratio, raised ROS, and increased ferrous iron, which potentially fuels the Fenton reaction, all of which contribute to greater bactericidal activity

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