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Key References Aronne LJ, Horn DB, le Roux CW, Ho W, Falcon BL, Gomez Valderas E, et al

Free-Radical Defense Neutralizes oxidative stress, the cellular wear-and-tear behind aging and fatigue

Pickart's 2012 review examined GHK-Cu's potential role in preventing oxidative stress and degenerative conditions of aging, with a focus on cognitive health implications

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Melatonin is synthesized in the pineal gland through the activation of two key enzymes: AANAT (arylalkylamine N-acetyltransferase) pCREB (phosphorylated cAMP response element-binding protein) In rat pinealocytes, Epitalon was shown to upregulate both AANAT and pCREB, suggesting a direct enzymatic stimulation of melatonin biosynthesis [56]