Clinical studies on appetite suppression A considerable number of studies have proven the effectiveness of semaglutide for weight loss, especially the STEP trials, which have been summarized below: Semaglutide clinical studies on appetite suppression Frequently asked questions How long does it take for semaglutide to work for weight loss
Choosing where to inject Ozempic Ozempic must be injected subcutaneously (under the skin, not into muscle or veins)
Accessed April 15, 2024.

Indications and Usage Wegovy (semaglutide) injection is indicated in combination with a reduced calorie diet and increased physical activity: To reduce the risk of major adverse cardiovascular (CV) events (CV death, non-fatal myocardial infarction, or non-fatal stroke) in adults with established CV disease and either obesity or overweight To reduce excess body weight and maintain weight reduction long term in: Adults and pediatric patients 12 years and older with obesity Adults with overweight in the presence of at least one weight-related comorbidity Wegovy (semaglutide) tablets are indicated in combination with a reduced calorie diet and increased physical activity to: Reduce the risk of major adverse cardiovascular (CV) events (CV death, non-fatal myocardial infarction, or non-fatal stroke) in adults with established CV disease and either obesity or overweight Reduce excess body weight and maintain weight reduction long term in adults with obesity or with overweight in the presence of at least one weight-related comorbidity Limitations of Use: Concomitant use of Wegovy tablets or Wegovy injection with other semaglutide-containing products or with any GLP-1 receptor agonist is not recommended References Wegovy [package insert]

This suggests that healthcare providers can use a dose-titration strategy to achieve the balance between weight-loss efficacy and tolerability for individual patients
GLP-1Rpositive neurons in the lateral septum mediate the anorectic and weight-lowering effects of liraglutide in mice