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It has been studied in controlled research settings focusing on endocrine signalling pathways and peptide-receptor interaction models

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Reininghaus EZ, Platzer M, Kohlhammer-Dohr A, et al

Similar findings have been observed in humans, indicating a connection between alcohol dependence and dopaminergic function

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Surprisingly, it was found that the Si-based agent not only relieved the intestinal symptoms associated with colitis but also the psychological symptoms such as visceral pain and discomfort