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Instead, research points to activity across multiple interconnected systems, including modulation of the nitric oxide (NO) system, upregulation of growth factor expression (notably VEGF, EGF, and FGF pathways), promotion of angiogenesis, and activation of the FAK-paxillin signalling pathway involved in cell migration and tissue organisation

Fat tissue produces an enzyme called aromatase, which converts testosterone into estrogen.The more fat you carry, the more aromatization occurs, which lowers available testosterone and raises estrogen

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