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But biological plausibility is not the same as clinical proof

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When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before

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A 2025 nutrition review found that high-protein breakfasts reduced afternoon hunger by almost twenty-five percent compared with carbohydrate-heavy ones

MASH is an advanced stage of metabolic dysfunction-associated steatotic liver disease (MASLD), a condition formerly known as nonalcoholic fatty liver disease