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Internalization separates the ligand from the receptor via the acidic endosomal route, where caveolin- or clathrin-dependent mechanisms may be used for internalization ( 4 The role of the IGF family in carcinogenesis The IGF family plays a critical role in various cellular processes such as proliferation, differentiation, and apoptosis ( Figure 1 )

Molecular Systems Biology

Over time, several epithelial stem/progenitor cell candidates have been proposed, as comprehensively reviewed in [24]

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