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N Engl J Med (2021) 385:50315

A severe-GI gate is present (gastroparesis / blockage / IBD), but that doesnt cover pancreatitis specifically

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10.1093/ajcn/nqab262 Am J Clin Nutr

In the context of the Melanotan II pathway, this suggests that MC1R-mediated signaling is more likely to function within the expected range, supporting a more typical receptor response to melanocortin-family ligands such as -MSH analogs