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(1992, Biochem J) demonstrated that IGF-1 and its variants including Long R3 IGF-1 are anabolic in dexamethasone-treated rats, confirming the utility of IGF-1 LR3 in models of catabolic states and muscle wasting where native IGF-1 activity is suppressed by glucocorticoid-driven IGFBP upregulation

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They are often grouped together but they have different mechanisms, different FDA statuses, different indications, different potency, and different side-effect profiles

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adults reported using GLP-1 medications for weight loss, more than double the percentage reported in early 2024