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Here we find increased proportion of pro-inflammatory and mesenchymal fibroblast subpopulations and senescent fibroblasts, and enhanced expression of senescence-associated secretory phenotype genes using single-cell RNA sequencing analysis, as well as elevated p16 protein and more -galactosidase-positive cells in keloids

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Bruckert E, Hayem G, Dejager S, Yau C, Bgaud B

FSP1 is recently identified as a breakthrough owing to its unique ability to suppress ferroptosis by reducing ubiquinone to ubiquinol 2,3 , or vitamin K to reduced hydroquinone (VKH2) 17