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In the U.S., Medicare price setting begins January 1, 2028, and the compound patent expires Dec 2028, making KEYTRUDAs loss of exclusivity arguably the largest single LOE by revenue on the near-term horizon

Given that the study involved a neuroimaging component, children with absolute contraindications to undergo magnetic resonance imaging were also excluded

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Of those, age affected predictions the most, followed by eGFR, urinary betaine, percentage of visceral body fat and serum butyryl-carnitine (Fig

Valastro B, Cossette J, Lavoie N, Gagnon S, Trudeau F, Massicotte G