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In contrast, GLP-1 receptor agonists are particularly effective in reducing major adverse cardiovascular events, while their effect on HF hospitalization appears more modest, with relative risk reductions of approximately 11% (HR 0.89) in pooled analyses [6, 14]

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Thus, the magnitude of semaglutide-induced diuresis is lower, but not completely ablated, with loss of the VSMC GLP-1R

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Patients at 15 mg lost an average of twenty-two percent of their body weight over sixty-eight weeks, compared to three percent for placebo