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These metabolic benefits translate into whole-body effects: for example, in diet-induced obesity models, MOTS-c administration prevented excessive weight gain and insulin resistance when mice were fed a high-fat diet, without affecting weight in lean diets

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BPC-157 corresponds to amino acids 14-28 of the larger Body Protection Compound protein originally isolated from human gastric juice, which appears to play a homeostatic role in gastrointestinal mucosal protection

MOTs-C may pose significant risk for immunogenicity for some routes of administration, the agency said in 2023