To test the possible increase in potency of the two drugs when given simultaneously, we injected a total volume of 4 ml of combined doses of L838,417 and CLP257 in a fixed dose ratio of \([{\mathrm{L 838,417]/[{\mathrm{CLP 257]\) = 1:55, given the relative EC50s of the two drugs calculated from the respective dose response curves with a priori assumption on the collapse at high doses of L838,417 (Fig
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Abstract Background Cerebral ischemic injury leads to over-activation of microglia, which release pro-inflammatory factors that deteriorate neurological function during the acute phase of stroke
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Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia
