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doi: 10.1038/s41467-017-00074-w 28 FentonH

they do not increase adrenaline, accelerate heart rate, or create the jittery sensation associated with caffeine or amphetamines

R., Drucker D

Tirzepatide has been associated with modest increases in resting heart rate (mean increase of 24 bpm in clinical trials), though the mechanism is unclear

6 Neurohormonal Mechanisms GLP-1RAs may modulate the activity of the autonomic nervous system by shifting the balance away from sympathetic overactivation towards parasympathetic tone