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High concentrations of T cell chemotactic chemokines (i.e., CXCL9 and CXCL10) are associated with irAEs (95)

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For example, the electrophysiological characteristics of dopaminergic neurons in the substantia nigra pars compacta change before the appearance of motor symptoms in parkinsonian mice (Qi et al., 2017), while excitatory stimulation of dopaminergic neurons may improve the survival of the neurons ( Medulla Oblongata and Pons The medullar oblongata in rodents and monkeys expresses a high level of GLP-1R ( The NTS is the main source of endogenous GLP-1 within the brain (Table 1)

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