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In MPP + -induced neurodegeneration in a rat model, several taurine analogs (taurine phosphonate, trimethyltaurine and guanidinoethane sulfonate) produced a protective effect via an extracellular mechanism

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doi: 10.1016/j.expneurol.2009.04.001 80

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Most users find that nausea resolves significantly by week 4, though some mild queasiness may linger into week 8

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