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Healthy kidney function is typically defined by an estimated glomerular filtration rate (eGFR) above 90 mL/min/1.73m without evidence of kidney damage, whilst chronic kidney disease (CKD) is classified into stages based on declining eGFR values and the presence of albuminuria, as outlined in NICE guideline NG203

Chaney KE, Perrino MR, Kershner LJ, Patel AV, Wu J, Choi K, et al

Y.AlzuwaydiA.EidR.et al (2022)

Additionally, transcriptome analysis and a functional GJ inhibitor have highlighted hepsin's mechanism for managing oxidative stress

Martindale JJ, Wall JA, Martinez-Longoria DM, Aryal P, Rockman HA, Guo Y, Bolli R, Glembotski CC: Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo

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