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The programme spans multiple trials targeting distinct endpoints: On 21 May 2026 Eli Lilly reported topline results from TRIUMPH-1, the pivotal Phase 3 obesity trial and the programme's first Phase 3 efficacy readout: in 2,339 adults, mean weight loss at the 80-week primary endpoint reached 19.0% (4mg), 25.9% (9mg), and 28.3% (12mg) versus 2.2% for placebo (Eli Lilly investor release
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Apamin has also been investigated for its potential in cancer treatment (Villa et al., 2020)
On the manufacturing and investment front, Amgen committed to major US expansions, including a $650 million upgrade of its Puerto Rico biologics manufacturing network expected to create hundreds of jobs and bolster supply chain resilience, alongside ongoing multi-hundred-million-dollar facility builds and innovation centers in North Carolina, Ohio, and California
The FDA approved encorafenib in 2018 in combination with the MEK inhibitor binimetinib