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FIGURE 8 3.8 Immunohistochemical findings The immunohistochemical investigation demonstrated a significant increase in expression of proapoptotic makers, Bax, and caspase-3, in MTX treated group, which was associated with decreased antiapoptotic marker, Bcl-2, expression when compared to the CTRL group (Figure 9)

A central mechanism often implicated is the dysfunction of Electron Transport Chain (ETC), which plays a crucial role in ATP production

Won JC, et al

Avoid over-exercising, which can trigger histamine release

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