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The new 5-HT hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

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Keeping a symptom diary during your first month on semaglutide helps you and your healthcare provider identify patterns and determine whether acid-reducing medication is truly necessary for your situation

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Besides increased flatulence in 2 patients from the intervention group, no other safety concerns were reported (Mitrovi et al., 2023)