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In order to adjust for confounders, the following covariate variables were selected as the independent variable: age, race, ethnicity, sex, BMI, history of chronic kidney disease (CKD), history of congestive heart failure (CHF), history of diabetes, history of gastric surgery, history of gastroparesis, whether bowel prep was used (e.g., underwent same day EGD-flexible sigmoidoscopy or EGD-colonoscopy), history of GLP-1RA use, and other medications known to contribute to delayed gastric emptying

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Brand-Name Costs (Without Insurance): Oral Semaglutide (Rybelsus): List Price: $900-$1,000 per month 30-day supply (30 tablets) Must take daily Annual cost: $10,800-$12,000 Injectable Semaglutide (Wegovy): List Price: $1,349 per month 4-5 weekly injections per pack Weekly dosing Annual cost: $16,188 Injectable Tirzepatide (Zepbound): List Price: $1,069 per month 4 weekly injections per pack Weekly dosing Annual cost: $12,828 With Insurance Coverage: Oral Semaglutide: More likely to be covered for diabetes Weight loss coverage varies Copay: $25-$300/month with insurance Prior authorization usually required Injectable Semaglutide (Wegovy): Covered by some insurance for weight loss Copay: $25-$300/month with insurance Extensive prior authorization requirements May require failed weight loss attempts first Injectable Tirzepatide (Zepbound): Newer to market, less insurance coverage for weight loss Copay: $25-$300/month with insurance Even more restrictive prior authorization Many plans dont cover yet for weight loss Compounded Injectable Options: Compounded Semaglutide: TrimRx price: $199/month with annual commitment Other providers: $199-$599/month No insurance coverage but HSA/FSA eligible Annual cost: $2,388-$7,188 Compounded Tirzepatide: TrimRx price: $349/month with annual commitment Other providers: $349-$699/month No insurance coverage but HSA/FSA eligible Annual cost: $4,188-$8,388 No Compounded Oral Options: Compounding pharmacies cannot create oral semaglutide because the SNAC absorption technology is proprietary and patented

When you take ibuprofen, you temporarily reduce these protective signals, which can leave the stomach lining more vulnerable to irritation