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Description

It has been shown that multiple apoptosis-regulating proteins are substrates for lysosome-derived cathepsins, including Bid, Bcl-2, Bcl-XL, and XIAP [62]

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Even though the pharmaceutical industry appears to have largely withdrawn its interest in pursuing the H3R as an anti-obesity target (189), work endures to optimize H3R ligands and explore their potential to influence food intake and body weight, and H3R antagonists/inverse agonists continue to be proposed for the treatment of obesity (190, 191)

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