We interpret the clinical and mechanistic data obtained for different agents that enable weight loss and glucose control for the treatment of obesity and type 2 diabetes mellitus, respectively, by activating or blocking GIPR signalling, including the GIPRGLP1R co-agonist tirzepatide, as well as the GIPR antagonistGLP1R agonist AMG-133
Those with means can buy marginal benefit
While formal evidence remains in development, the mechanistic rationale is compelling: sustained, gentle GLP-1 receptor activation may favorably influence glucose metabolism, cardiovascular integrity, and neuroprotection, all while maintaining tolerability and adherence
Future Challenges in Biopharmaceutical Workforce Development White Paper
Registration clinical trials show that 16-37% of patients discontinue within a year (109111)
Bahaa Elfakharany, Faculty of Allied Medical Sciences, Alexandria, Egypt