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However, the gastrointestinal side effects commonly associated with GLP-1 RAs, such as nausea, vomiting, diarrhea, bloating, constipation, pancreatitis, gastroparesis, and bowel obstruction, may affect long-term patient compliance and limit their widespread clinical use [84]

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Due to the rapid reduction in facial volume, semaglutide may also accelerate the aging process, altering the size, shape, and proportion of features such as the lips, chin, and cheeks

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