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Any modifications to the composition of this layer could negatively affect the joint and participate in the onset of OA [44]

In simple terms, GLP-1 agonists are drugs that copy the action of the natural hormone GLP-1, helping your body make insulin, reducing the amount of glucose your body needs to make, and slowing down food digestion to reduce hunger effectively

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A 2025 radiographic study found an average 7% reduction in midfacial volume for every 10 kilograms of total weight lost, with most of the change occurring in superficial facial fat pads