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Clinical trials, including SURMOUNT-1, used this dose as the entry point to assess tolerability before increasing

The PPAR sensitizers were reported to improve the hepatic histologic findings of ballooning, lobular inflammation, and steatosis in a meta-analysis that compared the use of Thiazolidinediones to placebo in 334 individuals, but no significant improvement of fibrosis was detected

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Some studies have described that the risk may be most pronounced when acetaminophen is taken chronically throughout pregnancy