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Variants in GLP1R (the GLP-1 receptor itself), GIPR (GIP receptor particularly rs1800437, the headline variant for differential GLP-1 response), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide

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New acylcarnitine ratio as a reliable indicator of long-chain 3-Hydroxyacyl-CoA dehydrogenase deficiency

Strength (2-3x weekly when ready): Bodyweight exercises or light resistance

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67% of Omada members remained on their GLP-1 medications for one year, surpassing the 47-49% persistence rate of comparable studies