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Scalp pruritus may also be a prominent feature of rare conditions such as dermatitis herpetiformis, lichen planopilaris and trigeminal trophic syndrome

12,13 Although the original approval was largely based on the potent glucose-dependent insulinotropic properties of GLP-1R activation on pancreatic -cells, it has become clear that the GLP-1R is expressed on a variety of other tissues, which produce a range of biological effects across diverse organ systems (Figure 2)

It may also enhance the activity of certain immune cells, which may ward off viruses and chronic disease such as cancer, according to a 2020 review in the medical journal, Nature (2)

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Existing Gut Sensitivities: People with conditions like irritable bowel syndrome (IBS) or other gastrointestinal issues may be more likely to experience diarrhea when taking semaglutide

On the other hand, phentermine stimulates the central nervous system and suppresses appetite, though the exact mechanism is not fully understood