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Conversely, the observed increase in heart rate associated with GLP-1 receptor agonists has raised concerns

It is being evaluated in clinical trials for safety and efficacy

This extended half-life provides some metabolic benefit during short interruptions but also means side effects may persist for several weeks after discontinuation

The cardiovascular benefits of GLP-1RAs are well-established, with clinical trials demonstrating reductions in major adverse cardiovascular events (MACE), improved endothelial function, and lower blood pressure

Symptoms include trembling, sweating, confusion, palpitations, hunger, and irritability

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