doi: 10.1016/S2213-8587(22)00045-6 73 VenturaR
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When the central repressors of ferroptosis, such as glutathione (GSH) and lipid enzyme glutathione peroxidase 4 (GPX4) [103], which participate in peroxide reduction and reduce product toxicity, show insufficient activity, the lipid radicals formed cannot be cleared and continue to generate new oxidative products via chain reaction
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The cytoprotection concept holds innate cell (epithelial (Robert) [41,42,43], endothelial (Szabo) [44,45,46,47]) integrity, even against opposite damaging necrotizing agents (i.e., strong alcohol, boiling water, strong acid, strong base [41]) and protection/maintenance/reestablishment in the stomach to be translated to other organ therapy (cytoprotection organoprotection) [48,49] via the cytoprotection agents effect
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