B :
In a double blinded phase 2 study, T2DM and obese patients were treated with CagriSema, Semaglutide alone or Cagrlinitide alone (All escalated to 2.4 mg)
Okuyama C, Higashi T, Ishizu K, Saga T
Warning signs include severe, persistent upper abdominal pain that may radiate to the back, persistent nausea and vomiting, fever, and abdominal tenderness
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Of note, toxicity can occur at serum concentrations that are lower than expected because LAs accumulate in mitochondria and cardiac tissue at a ratio of about 6:1 (or greater) relative to plasma