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GLP-1 agonists, such as Trulicity (dulaglutide), also provide cardiovascular protection and are FDA-approved to reduce the risk of major cardiovascular events in diabetes patients with heart disease or related risk factors

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Regulatory bodies including the MHRA and European Medicines Agency (EMA) continue to monitor safety data, and current product information for GLP-1 agonists includes cholelithiasis and cholecystitis as recognised adverse reactions