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Despite Pa DHDPR sharing 42% sequence identity with DHDPR from Anabaena variabilis [ Av DHDPR

Folic acid congeners are transported across cells by receptor-mediated endocytosis where they function and are stored

[5] [6] Early-phase clinical trials including a Phase 2 trial published in the New England Journal of Medicine (2023) have reported significant reductions in body weight and improvements in metabolic markers, though this evidence remains preliminary and is not sufficient to establish a clinical dosing or reconstitution standard

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doi:10.2147/CCID.S128339 Handog EB, Datuin MS, Singzon IA